Page 17 - Demo
P. 17
Journal of Rural Medicine%u4e61%u6751%u533b%u5b66%u7b2c 2 %u5377%u25c6%u7b2c 4 %u671f%u25c6%u7248%u672c 1.0 %u25c6 2025 %u5e74%u6587%u7ae0%u7c7b%u578b%uff1a%u8bba%u6587 | %u520a%u53f7%uff08ISSN%uff09%uff1a3060-947X11 Copyright %u00a9 This work is licensed under a Commons Attibution-Non Commercial 4.0 International License.%u4e0d%u7b26%u5408%u7eb3%u5165%u6807%u51c6%uff0c%u56e0%u6b64%u6700%u7ec8%u7eb3%u5165%u672c%u7814%u7a76%u7684%u60a3%u8005%u6570%u91cf%u6709%u9650%uff1b%u5176%u6b21%uff0c%u7ed9%u836f%u65b9%u5f0f%u548c%u5242%u91cf%u4e5f%u662f%u5f71%u54cd%u836f%u7269%u8840%u836f%u6d53%u5ea6%u7684%u91cd%u8981%u56e0%u7d20%uff0c%u4f8b%u5982%uff0c%u6709%u7814%u7a76%u5efa%u8bae%u5728%u6cbb%u7597%u7cbe%u795e%u5206%u88c2%u75c7%u9633%u6027%u75c7%u72b6%u7684%u8d77%u59cb%u5242%u91cf%u4e3a 400-800mg/d%uff0c%u5bf9%u4e8e%u4e3b%u8981%u51fa%u73b0%u9634%u6027%u75c7%u72b6%u7684%u60a3%u8005%u4e3a 50-300mg/d[101]%uff0c%u6b64%u5916%uff0c%u6709%u7814%u7a76%u8868%u660e%u6c28%u78fa%u5fc5%u5229%u836f%u7269%u5242%u91cf%u5728 594%u00b1262mg/d %u65f6%uff0c%u60a3%u8005%u8840%u836f%u6d53%u5ea6%u663e%u8457%u9ad8%u4e8e%u63a8%u8350%u76d1%u6d4b%u6d53%u5ea6 [102]%u3002%u5728%u7ed9%u836f%u65b9%u5f0f%u4e0a%uff0c%u76ee%u524d AGNP %u6307%u5357%u4e2d%u63a8%u8350%u7684%u7ed9%u836f%u65b9%u6848%u4e3a%u6bcf%u65e5%u5355%u6b21%u7ed9%u836f%uff0c%u540c%u65f6%u91c7%u8840%u65f6%u95f4%u4e3a%u672b%u6b21%u670d%u836f%u540e%u7684 24h%uff0c%u836f%u54c1%u8bf4%u660e%u4e66%u5219%u5efa%u8bae%u5242%u91cf%u9ad8%u4e8e 400mg/d %u6bcf%u65e5%u5206%u4e24%u6b21%u670d%u7528%u3002%u7136%u800c%uff0c%u5728%u5b9e%u9645%u6cbb%u7597%u8fc7%u7a0b%u4e2d%uff0c%u60a3%u8005%u7684%u75c5%u60c5%u53d1%u5c55%u5b58%u5728%u9636%u6bb5%u6027%uff0c%u56e0%u800c%u7ed9%u4e88%u60a3%u8005%u7684%u836f%u7269%u5242%u91cf%u548c%u65b9%u5f0f%u5b58%u5728%u53d8%u5316%uff0c%u56e0%u6b64%u672c%u7814%u7a76%u672a%u6df1%u5165%u63a2%u8ba8%u7ed9%u836f%u65b9%u5f0f%u5bf9%u4e8e%u8840%u836f%u6d53%u5ea6%u7684%u5f71%u54cd%u3002%u7efc%u4e0a%uff0c%u672c%u7814%u7a76%u57fa%u4e8e%u771f%u5b9e%u7684%u4e34%u5e8a%u8bca%u7597%u6570%u636e%uff0c%u901a%u8fc7%u56de%u987e%u7cbe%u795e%u75c5%u5206%u88c2%u75c7%u60a3%u8005%u4f4f%u9662%u671f%u95f4%u5e94%u7528%u6c28%u78fa%u5fc5%u5229 TDM%u7ed3%u679c%uff0c%u8868%u660e BMI %u662f%u5f15%u8d77%u6c28%u78fa%u5fc5%u5229%u8840%u836f%u6d53%u5ea6%u4e2a%u4f53%u5316%u5dee%u5f02%u7684%u91cd%u8981%u5f71%u54cd%u56e0%u7d20%uff0cROC %u548c%u4e0d%u826f%u53cd%u5e94%u76f8%u5173%u6027%u5206%u6790%u63d0%u793a%u5f53%u6cbb%u7597%u6709%u6548%u7387%u8fbe 50% %u65f6%uff0c%u6c28%u78fa%u5fc5%u5229%u8840%u836f%u6d53%u5ea6%u4e3a487.8ng/mL %u5e76%u8868%u73b0%u51fa%u826f%u597d%u7684%u5b89%u5168%u6027%uff0c%u4e3a%u5236%u5b9a%u9002%u7528%u4e8e%u4e2d%u56fd%u7cbe%u795e%u5206%u88c2%u75c7%u60a3%u8005%u7684%u6c28%u78fa%u5fc5%u5229%u8840%u836f%u6d53%u5ea6%u76d1%u6d4b%u8303%u56f4%u63d0%u4f9b%u4e86%u91cd%u8981%u53c2%u8003%u3002%u3010%u53c2%u8003%u6587%u732e%u3011[1] R%u00f6ssler W, Salize H J, Van Os J, et al. Size of burden ofschizophrenia and psychotic disorders[J]. Eur Neuropsychopharmacol, 2005, 15(4): 399-409.[2] Chong H Y, Teoh S L, Wu D B, et al. Global economic burdenof schizophrenia: a systematic review[J]. Neuropsychiatr Dis Treat, 2016, 12(1): 357-73.[3] Charlson F J, Ferrari A J, Santomauro D F, et al. GlobalEpidemiology and Burden of Schizophrenia: Findings From the GlobalBurden of Disease Study 2016[J]. Schizophr Bull, 2018, 44(6): 1195-1203.[4] Lieberman J A. Disease modifying effects of antipsychotic drugsin schizophrenia: a clinical and neurobiological perspective[J]. WorldPsychiatry, 2018, 17(2): 163-165.[5] %u7a0b%u541b%uff0c%u590f%u5b88%u7fe0%uff0c%u6c6a%u8d85%uff0c%u7b49 . %u6c28%u78fa%u5fc5%u5229%u4e0e%u5229%u57f9%u916e%u5bf9%u5973%u6027%u9996%u53d1%u7cbe%u795e%u5206%u88c2%u75c7%u60a3%u8005%u751f%u5316%u6307%u6807%u7684%u5f71%u54cd [J]. %u4e34%u5e8a%u5fc3%u8eab%u75be%u75c5%u6742%u5fd7%uff0c 2017%uff0c23(4): 28-30.[6] %u97e9%u7b11%uff0c%u5d14%u5229%u519b%uff0c%u9b4f%u5fd7%u521a%uff0c%u7b49 . %u516d%u79cd%u975e%u5178%u578b%u6297%u7cbe%u795e%u75c5%u836f%u7269%u6cbb%u7597%u7cbe%u795e%u5206%u88c2%u75c7%u5bf9%u60a3%u8005%u5185%u5206%u6ccc%u7684%u5f71%u54cd [J]. %u4e2d%u56fd%u8001%u5e74%u5b66%u6742%u5fd7%uff0c2019%uff0c39(23): 5752-5754.[7] Juruena M F, De Sena E P, De Oliveira I R. Safety andtolerability of antipsychotics: focus on amisulpride[J]. Drug HealthcPatient Saf, 2010, 2(2): 205-211.[8] Leucht S, Cipriani A, Spineli L, et al. Comparative efficacyand tolerability of 15 antipsychotic drugs in schizophrenia: a multipletreatments meta-analysis[J]. Lancet, 2013, 382(9896): 951-962.[9] Brown D L, Masselink A J, Lalla C D. Functional range ofcreatinine clearance for renal drug dosing: a practical solution to thecontroversy of which weight to use in the Cockcroft-Gault equation[J]. Ann Pharmacother, 2013, 47(7-8): 1039-1044.[10] %u5e94%u7fd4%uff0c%u7a0b%u97ec%uff0c%u6c88%u5b66%u8c26%uff0c%u7b49 . %u7cbe%u795e%u5206%u88c2%u75c7%u60a3%u8005%u6c28%u78fa%u5fc5%u5229%u8840%u836f%u6d53%u5ea6%u4e0e%u4e0d%u826f%u53cd%u5e94%u3001%u6ccc%u4e73%u7d20%u6c34%u5e73%u53ca%u8ba4%u77e5%u529f%u80fd%u76f8%u5173%u6027 [J]. %u4e2d%u56fd%u73b0%u4ee3%u5e94%u7528%u836f%u5b66%uff0c2022%uff0c39(11): 1464-1469.[11] Lynch M J, Woods J, George N, et al. Fatality due toamisulpride toxicity: a case report[J]. Med Sci Law, 2008, 48(2): 173-177.[12] Hiemke C, Bergemann N, Clement H W, et al. ConsensusGuidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017[J]. Pharmacopsychiatry, 2018, 51(1-02): 9-62.[13] Ding J, Yang L, Cui X, et al. A 5-year retrospective study

