Accelerating the transformation of scientific and technological achievements is an important part of deeply implementing the innovation-driven development strategy, promoting the high-quality development of the economy and society, and enhancing the comprehensive national competitiveness. In recent years, the innovation capabilities of universities have been continuously improved, and a large number of scientific research achievements have emerged. However, the conversion rate of scientific and technological achievements is relatively low, and the contribution to regional economies and local development is insufficient. This article analyzes the problems faced by the transformation of scientific and technological achievements in universities at the current stage from three aspects: the constraints of the scientific research evaluation system in universities, the serious connection obstacles between the supply and demand of scientific and technological achievements, and the lack of professional talents in technology transfer. It also proposes how to start from aspects such as reforming the scientific research evaluation system in universities, strengthening the orientation of market demand, and introducing and cultivating high-level technology managers, so as to give play to the advantages of universities as scientific and technological think tanks and promote the simultaneous improvement of the quantity and quality of the transformation of scientific and technological achievements in universities.